IL18BP Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL18BP (Interleukin 18 Binding Protein, also known as FVH; IL18BPa), located on 11q13.4, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 21099 Da protein composed of 194 amino acids. The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. Diseases such as Hepatitis, Fulminant Viral, and Molluscum Contagiosum are associated with IL18BP. The related pathways of IL18BP include Innate Immune System and Cytokine Signaling in the Immune system.

IL18BP Protein (4)

    IL18BP Antibody (7)

      IL18BP ELISA Kit & Match Antibody ELISA Pair Set (1)

      IL18BP cDNA Clone (26)

      NM_001039659.1

      In expression vector

      NM_010531.1
      NM_053374.2

      IL18BP Lysate (4)

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        IL18BP Background

        Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.

        IL18BP References

        • Novick D, et al.. (2001) A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18. Cytokine. 14(6): 334-42.
        • Mazodier K, et al.. (2005) Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome. Blood. 106(10): 3483-9.
        • Akira S. (2000) The role of IL-18 in innate immunity. Curr Opin Immunol. 12(1): 59-63.

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