IL12RB1 Proteins, Antibodies, cDNA Clones Research Reagents

IL12RB1 (Interleukin 12 Receptor Subunit Beta 1, also known as CD212; IMD30; IL12RB; IL-12R-BETA1), located on 19p13.11, is a Protein Coding gene. The gene produces a 73109 Da protein composed of 662 amino acids. IL12RB1 Functions as an interleukin receptor that binds interleukin-12 with low affinity and is involved in IL12 transduction. IL12RB1 is a receptor chain that combines with IL12RB2 to form the receptor for IL12. Alternatively, IL12RB1 can combine with IL23R to form the receptor for IL23. Diseases such as Immunodeficiency 30 and Salmonellosis are associated with IL12RB1.

IL12RB1 Protein (1)

    IL12RB1 Antibody (3)

      IL12RB1 cDNA Clone (13)

      NM_005535.1

      IL12RB1 qPCR Primer (1)

      IL12RB1 Lysate (1)

        IL12RB1 Background

        Interleukin 12 receptor, beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1(CD212) is a subunit of the interleukin 12 receptor. IL12RB1(CD212) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukin 12 (IL12) with a low affinity and is thought to be a part of the IL12 receptor complex. IL12RB1(CD212) forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of IL12RB1 and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. IL12RB1(CD212) Functions as an interleukin receptor that binds interleukin-12 with low affinity and is involved in IL12 transduction. It is associated with IL12RB2 it forms a functional, high-affinity receptor for IL12. IL12RB1(CD212) associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

        IL12RB1 References

        • Cleary AM, et al. (2003) Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta 1 deficiency. J Immunol. 170 (1): 597-603.
        • Suzuki Y, et al. (1997) Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. Gene. 200 (1-2): 149-56.
        • Yamamoto K, et al. (1997) Assignment of IL12RB1 and IL12RB2, interleukin-12 receptor beta 1 and beta 2 chains, to human chromosome 19 band p13.1 and chromosome 1 band p31.2, respectively, by in situ hybridization. Cytogenet. Cell Genet. 77 (3-4): 257-8.

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