IL10RB Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL10RB (Interleukin 10 Receptor Subunit Beta, also known as CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2), located on 21q22.11, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 36995 Da protein composed of 325 amino acids. The protein encoded by this gene belongs to the cytokine receptor family. Diseases such as Inflammatory Bowel Disease 25, Autosomal Recessive, and Inflammatory Bowel Disease 25 are associated with IL10RB. The related pathways of IL10RB include Tuberculosis and AKT Signaling Pathway.

IL10RB Protein (5)

    IL10RB Antibody (11)

      IL10RB ELISA Kit & Match Antibody ELISA Pair Set (2)

      IL10RB cDNA Clone (52)


      IL10RB Lysate (5)

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        IL10RB Background

        Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-10 receptor. IL10RB/IL-10RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins is required for IL10-induced signal transduction. Defects in IL10RB/IL-10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn's disease and ulcerative colitis phenotypes. Crohn's disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

        IL10RB References

        • Josephson K, et al. (2001) Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity. 15 (1): 35-46.
        • Yoo KH, et al. (2011) Association of IL10, IL10RA, and IL10RB polymorphisms with benign prostate hyperplasia in Korean population. J Korean Med Sci. 26(5): 659-64.

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