IL-5 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL5 (Interleukin 5, also known as EDF; TRF; IL-5), located on 5q31.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 15238 Da protein composed of 134 amino acids. This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL-5 was originally found as an eosinophil colony-stimulating factor. Diseases such as Pulmonary Eosinophilia and Chronic Eosinophilic Pneumonia are associated with IL5. The related pathways of IL5 include RET signaling and Signaling by GPCR.

IL-5 Protein (7)

IL-5 Antibody (13)

    IL-5 ELISA Kit & Match Antibody ELISA Pair Set (2)

    IL-5 cDNA Clone (65)


    IL-5 Lysate (6)

      IL-5 Background

      Interleukin 5 (IL-5) is a member of the interleukin family with a length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered a key mediator in eosinophil activation. Interleukin 5 (IL-5) has long been associated with several allergic diseases, including allergic rhinitis and asthma. Growth in the number of circulating, airway tissue, and induced sputum eosinophils have been observed in patients with these diseases. IL-5 also had something with the terminally differentiated granulocyte eosinophils. IL-5 was originally found as an eosinophil colony-stimulating factor. It has been proved to be a major regulator of eosinophil accumulation in tissues and can modulate eosinophil behavior at every stage from maturation to survival.

      IL-5 References

      • Milburn MV, et al. (1993) A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. Nature. 363(6425): 172-176.
      • Lee JS, et al. (1989) The IL-4 and IL-5 genes are closely linked and are part of a cytokine gene cluster on mouse chromosome 11. Somat Cell Mol Genet. 15(2): 143-152.
      • Woodcock JM, et al. (1994) Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 13 (21): 5176-85.

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