IL-37 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL37 (Interleukin 37, also known as FIL1; FIL1Z; IL-1H; IL-23; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)), located on 2q14.1, is conserved in Rhesus monkey, dog, and cow. The gene produces a 24126 Da protein composed of 218 amino acids. The protein encoded by this gene is a member of the interleukin 1 cytokine family. Diseases such as Idiopathic Anterior Uveitis and Adult-Onset Still's Disease are associated with IL37. The related pathways of IL37 include PEDF Induced Signaling and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions.

IL-37 Protein (1)

    IL-37 Antibody (3)

      IL-37 ELISA Kit & Match Antibody ELISA Pair Set (1)

      IL-37 cDNA Clone (1)


      In cloning vector

      IL-37 qPCR Primer (1)

      IL-37 Background

      Interleukin 1 family member 7, or interleukin 37 (IL1F7 / IL37 / IL-1H4) is a secretory protein belonging to the Interleukin 1 family. IL-1F7 was localized in human peripheral monocytic cells. It has been localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7 may be involved in immune response, inflammatory diseases, and/or cancer. Through constructing an adenoviral vector that allows high-level expression in murine and human cells, it has been demonstrated that the ability of adenovirus-mediated gene transfer of IL1F7 to induce an IL-12- and Fas ligand-dependent anti-tumor response. Complete inhibition of tumor growth was observed following multiple injections of IL1F7 in most animals. These results suggest that IL1F7 could play a role in both innate and adaptive immune responses, similar to IL-18. Moreover, IL1F7 could be useful for cancer gene therapy.

      IL-37 References

      • Gao W, et al. (2003) Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity. J Immunol. 170 (1): 107-13.
      • Bufler P, et al. (2002) A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity. Proc Natl Acad Sci. 99 (21): 13723-8.
      • Kumar S, et al. (2002) Interleukin-1F7B (IL-1H4 / IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production. Cytokine. 18 (2): 61-71.

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