IL-35 Proteins Research Reagents

IL12A, together with IL27B, form a disulfide-linked heterodimer: IL12A&IL27B. IL12A&IL27B is necessary for the T-cell-independent induction of IFN-γand is important for the differentiation of both Th1 and Th2 cells. Nitric oxide synthase 2A (NOS2A/NOS2) is required for the signaling process of IL12A&IL27B in innate immunity. IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of Epstein-Barr virus (EBV)-induced gene-3 (EBI3, also known as IL27B) and the ubiquitously expressed p35 subunit of IL12.

IL-35 Protein (3)

    IL-35 Lysate (3)

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      IL-35 Background

      IL12A is a subunit of a cytokine that acts on T and natural killer cells and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. IL12A, together with IL27B, form a disulfide-linked heterodimer: IL12A&IL27B. IL12A&IL27B is required for the T-cell-independent induction of IFN-gamma and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of IL12A&IL27B in innate immunity.

      IL-35 References

      • Wolf S.F., et al.,(1991), Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 146:3074-3081.
      • Gubler U., et al., (1991), Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.Proc. Natl. Acad. Sci. U.S.A. 88:4143-4147.
      • Batten M., et al.,(2007), The biology and therapeutic potential of interleukin 27.J. Mol. Med. 85:661-672.

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