IL-23 P19/IL23A Proteins, Antibodies, cDNA Clones Research Reagents

IL23A (Interleukin 23 Subunit Alpha, also known as P19; SGRF; IL-23; IL-23A; IL23P19), located on 12q13.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 20730 Da protein composed of 189 amino acids. This gene encodes a subunit of the heterodimeric cytokine IL23. IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family. Diseases such as Multiple Sclerosis and Inflammatory Bowel Disease are associated with IL23A. The related pathways of IL23A include Tuberculosis and PEDF Induced Signaling.
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All IL-23 P19/IL23A Reagents

IL-23 P19/IL23A General Information

IL-23 P19/IL23A Protein (2)

Species

    IL-23 P19/IL23A Antibody (3)

    Application:
    Clonality:
    Host:

      IL-23 P19/IL23A cDNA Clone (62)

      BC067511

      In expression vector

      untagged

      C-GFPSpark C-DDK tag N-DDK tag C-His tag C-HA tag C-Myc

      In lentiviral vector

      C-GFPSpark
      NM_031252.2

      In cloning vector

      In cloning vector

      In expression vector

      untagged

      C-GFPSpark C-OFPSpark C-DDK tag N-DDK tag C-His tag N-His tag C-HA tag N-HA tag C-Myc N-Myc

      In lentiviral vector

      C-GFPSpark
      NM_130410.2

      In cloning vector

      In cloning vector

      In expression vector

      untagged

      C-GFPSpark C-OFPSpark C-DDK tag N-DDK tag C-His tag N-His tag C-HA tag N-HA tag C-Myc N-Myc

      In lentiviral vector

      C-GFPSpark
      XM_538231.3

      In cloning vector

      In cloning vector

      XM_002711079.1

      In cloning vector

      In cloning vector

      In expression vector

      untagged

      C-GFPSpark C-OFPSpark C-DDK tag N-DDK tag C-His tag N-His tag C-HA tag N-HA tag C-Myc N-Myc

      In lentiviral vector

      C-GFPSpark
      XM_002752608.1

      In cloning vector

      In cloning vector

      In expression vector

      untagged

      C-GFPSpark C-OFPSpark C-DDK tag N-DDK tag C-His tag N-His tag C-HA tag N-HA tag C-Myc N-Myc

      In lentiviral vector

      C-GFPSpark
      NM_001194669.1

      In expression vector

      untagged

      IL-23 P19/IL23A qPCR Primer (3)

      IL-23 P19/IL23A Lysate (2)

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        IL-23 P19/IL23A Background

        IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised of a unique p19 subunit and p4 subunit, the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rβ1, the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.

        IL-23 P19/IL23A References

        • Ye X, Zhang L, Wang H, et al. The Role of IL-23/Th17 Pathway in Patients with Primary Immune Thrombocytopenia. Kuwana M, ed. PLoS ONE. 2015;10(1):e0117704.

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