IL-18 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL18 (Interleukin 18, also known as IGIF; IL-18; IL-1g; IL1F4), located on 11q23.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 22326 Da protein composed of 193 amino acids. The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells and stimulates interferon-gamma production in T-helper type I cells. Diseases such as Adult-Onset Still's Disease and Shigellosis are associated with IL18. The related pathways of IL18 include Cellular roles of Anthrax toxin and Tuberculosis.

IL-18 Protein (4)

    IL-18 Antibody (14)

      IL-18 ELISA Kit & Match Antibody ELISA Pair Set (4)

      IL-18 cDNA Clone (65)

      NM_001562.2
      NM_008360.1
      NM_019165.1
      NM_001032834.2
      NM_001003169.1

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      IL-18 Background

      Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1-like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cell -, IL-4- and STAT6-dependent fashion. IL-18 and T cell receptor-mediated stimulation could induce naive CD4+ T cells to develop into IL-4-producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in the regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL-1β, suggesting that monokine expression can feedback to promote Th1 cell development in the synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA.

      IL-18 References

      • Dinarello CA. (1999) IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol. 103: 11-24.
      • Takeda K, et al.. (1998) Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity. 8(3): 383-90.
      • Gracie JA, et al.. (1999) A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest. 104(10): 1393-401.

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