IKB beta/NFKBIB Proteins, Antibodies, cDNA Clones Research Reagents

NFKBIB (NFKB Inhibitor Beta, also known as IKBB; TRIP9), located on 19q13.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish. The gene produces a 37771 Da protein composed of 356 amino acids. The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Diseases such as Ectodermal Dysplasia 11A, Hypohidrotic/Hair/Tooth Type, Autosomal Dominant and Ectodermal Dysplasia 11B, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive are associated with NFKBIB. The related pathways of NFKBIB include GDNF-Family Ligands and Receptor Interactions and Apoptosis Modulation and Signaling.

IKB beta/NFKBIB Protein (1)

    IKB beta/NFKBIB Antibody (2)

      IKB beta/NFKBIB cDNA Clone (17)

      AK290569.1

      In cloning vector

      In lentiviral vector

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      IKB beta/NFKBIB Background

      NFKBIB (NFKB Inhibitor Beta) is a Protein Coding gene. The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. NF-kappaB regulation involves the inhibitor protein NFKBIB, which form complexes with NF-kappaB to sequester it in the cytoplasm. Overexpression of NFKBIB protein in IAV infected cells led to lower levels of IAV. MiR-20a could promote activation of the NFkappaB pathway and downstream targets Livin and Survivin by targeting NFKBIB, which potentially contributed to GC chemoresistance.

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