Immunohistochemistry (IHC) Antibody-Kindey Tissue

Immunohistochemistry, using the basic principles of immunology - the antigen-antibody reaction, namely antigen and antibody specific binding principle, by chemical reaction of the labeled antibody reagent (luciferase, an enzyme, metal ions, isotopes) to confirm the antigens (peptides and proteins) in tissues, its location, qualitative and quantitative research, called immunohistochemistry (immunohistochemistry) or immunocytochemistry techniques (immunocytochemistry).It combined the specific of immune response with visibility of histochemistry by means of a microscope (including fluorescence microscopy, electron microscopy) imaging and amplification, detection of various antigens in a cell, subcellular level, such as proteins, polypeptides, enzymes, hormones, pathogens, and receptors. Immunohistochemical techniques have developed rapidly in recent years. It was limited to immunofluorescence techniques in 1950s, but gradually developed after the 1950s to establish a highly sensitive and more practical immunization enzyme technology.

The kidneys are a pair of organs located in the back of the abdomen. The kidneys perform the essential function of removing waste products from the blood and regulating the water fluid levels. Kidneys are essential to the urinary system. They provide predetermined functions such as self-balancing electrolytes, maintaining acid-base balance, regulation of blood pressure. They are serve as a blood filter and remove water-soluble waste transfer to the bladder. They are also responsible for the reabsorption of water, glucose and amino acids. Kidneys also produce hormones including calcitriol and erythropoietin. An important enzyme renin is also produced in the kidneys which acts in negative feedback. Kidney cancer which also called renal cancer is a disease in which kidney cells become malignant (cancerous) and grow out of control, forming a tumor. It is one of the ten most common cancers in both men and women. There are different types of kidney cancer. Approximately 90% of kidney cancer is renal cell carcinoma (RCC), sometimes also called renal adenocarcinoma. They began in the cells that line very small tubes in the kidney cortex., called tubules, There are different types of renal cell cancer. The most common type is clear cell renal cancer. Less common types are papillary, chromophobe and collecting duct renal cancer. Another type of kindey cancer are transitional cell cancers which can affect the kidneys starts in the cells that line the renal pelvis, where the kidney joins with the ureter. Of all kidney cancers, only about 7 out of 100 (7%) begin in the renal pelvis, and 5 out of 100 (5%) in the ureter.

Different species of kindey slices as follows: