IGFBP1 Proteins, Antibodies, cDNA Clones Research Reagents

IGFBP1 (Insulin-Like Growth Factor Binding Protein 1, also known as AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1), located on 7p12.3, is a Protein Coding gene. The gene produces a 27904 Da protein composed of 259 amino acids. The low molecular weight IGF-binding protein (IGFBP1) is synthesized in the liver, secretory endometrium, and decidua. It binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Diseases such as Ovarian Disease and Hyperinsulinism are associated with IGFBP1. The related pathways of IGFBP1 include PERK regulates gene expression and Myometrial Relaxation and Contraction Pathways.

IGFBP1 Protein (2)

    IGFBP1 Antibody (1)

      IGFBP1 cDNA Clone (41)

      NM_000596.2
      NM_008341.4
      NM_013144.1

      In cloning vector

      In lentiviral vector

      XM_001085935.2

      IGFBP1 qPCR Primer (1)

      IGFBP1 Lysate (2)

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        IGFBP1 Background

        IGFBP1, also known as IGFBP-1 and insulin-like growth factor-binding protein 1, is a member of the insulin-like growth factor-binding protein family. IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. All six IGFBPs share 50% homology and have binding affinities for IGF-I and IGF-II at the same order of magnitude as the ligands have for the IGF-IR. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth-promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGFBP1 has an IGFBP domain and a thyroglobulin type-I domain. It binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. The binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

        IGFBP1 References

        • Wood AW, et al. (2005) Insulin-like growth factor signaling in fish. Int Rev Cytol. 243:215-85.
        • Firth SM, et al. (2003) Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev. 23 (6):824-54.
        • Ferry RJ, et al. (1999) Insulin-like growth factor binding proteins: new proteins, new functions. Horm Res. 51(2):53-67.

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