IFN-omega Proteins, Antibodies, cDNA Clones Research Reagents

IFNW1 (Interferon Omega 1), located on 9p21.3, is conserved in chimpanzee, Rhesus monkey, and cow. The gene produces a 22319 Da protein composed of 195 amino acids. The protein encoded by this gene is interferon and possesses antiviral activity. Diseases such as Syndromic X-Linked Intellectual Disability Cabezas Type and Melanoma, Cutaneous Malignant 1 are associated with IFNW1. The related pathways of IFNW1 include all-trans-retinoic Acid Mediated Apoptosis and Interferon Pathway.

IFN-omega Protein (2)

    IFN-omega Antibody (3)

      IFN-omega cDNA Clone (13)


      IFN-omega qPCR Primer (1)

      IFN-omega Lysate (2)

        IFN-omega Background

        IFNs are a large family of proteins having antiviral, antiproliferative, and immunomodulatory effects, and are divided into two major classes, type I and type II, based on differences in receptor binding and nucleotide sequence. Type I IFNs consist of IFN α, β, τ, and ω and bind to the type I IFN receptor, whereas IFN-γ is the only type II IFN and is specific for the type II IFN receptor. Human IFN-ω, was identified by three independent groups in 1985 and is structurally related to IFN-α and -β. Both human IFN-ω and IFN-α are produced by virally induced leukocytes and have similar antiviral activities on human cell lines, and a sizeable proportion (at least 1%) of the total antiviral activity of leukocyte IFN is contributed by IFN-ωl. Also, it was reported that IFN-ω could inhibit the growth of human tumors in vivo.

        IFN-omega References

        • Capon D.J., et al.,(1985), Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides. Mol. Cell. Biol. 5:768-779.
        • Adolf G.R., et al., (1991), Human interferon omega 1: isolation of the gene, expression in Chinese hamster ovary cells and characterization of the recombinant protein.Biochim. Biophys. Acta 1089:167-174.
        • Humphray S.J., et al.,(2004), DNA sequence and analysis of human chromosome 9.Nature 429:369-374.

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