ICOS ligand Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

ICOSLG (Inducible T Cell Costimulator Ligand, also known as B7h; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L), located on 21q22.3, is a Protein Coding gene. The gene produces a 33349 Da protein composed of 302 amino acids. ICOSLG binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Sequence analysis predicted that the protein contains a transmembrane domain and 5 conserved cysteine residues.

ICOS ligand Protein (9)

    ICOS ligand Antibody (13)

      ICOS ligand ELISA Kit & Match Antibody ELISA Pair Set (1)

      ICOS ligand cDNA Clone (28)

      NM_001283050.1

      In expression vector

      NM_015259.4
      NM_015790.3
      XM_006256262.1

      In cloning vector

      XM_005548562.3

      In cloning vector

      ICOS ligand Lysate (8)

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        ICOS ligand Background

        Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.

        ICOS ligand References

        • Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
        • Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
        • Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.

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