HuR/ELAVL1 Antibodies, cDNA Clones Research Reagents

All HuR/ELAVL1 reagents are produced in house and quality controlled, including 3 HuR/ELAVL1 Antibody, 17 HuR/ELAVL1 Gene, 1 HuR/ELAVL1 IP Kit. All HuR/ELAVL1 reagents are ready to use.

HuR/ELAVL1 Antibody (3)

    HuR/ELAVL1 cDNA Clone (17)

    NM_001419.2

    In cloning vector

    In expression vector

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    HuR/ELAVL1 Background

    HuR/Elav-like RNA binding protein 1 (ELAVL1) positively regulates mRNA stability of AU-rich elements (ARE)-containing transcript such as pro-inflammatory cytokines. Ribotoxic stresses can trigger the production of pro-inflammatory mediators by enhancing mRNA stability and the transcriptional activity. We investigated the effects of ribotoxin deoxynivalenol (DON) on HuR translocation and its involvement in the regulation of the pro-inflammatory interleukin-8 (IL-8) mR. ELAVL1 is an RNA binding protein involved in translation control, which might have a regulatory role in prostate cancer progress. ELAVL1 is an RNA binding protein involved in translation control, which might have a regulatory role in prostate cancer progress. EIF5A2, eukaryotic translation initiation factor 5A2, is associated with several human cancers. Overexpression of EIF5A2 was an independent predictor for poor metastasis-free survival of localised invasive BC patients treated with radical cystectomy. eIF5A2 is overexpressed by gene amplification or hypoxia in ESCCs, and associated with up-regulation of HIF1alpha, metastasis, and shorter survival times of patients. Increased expression of eIF5A2 increases metastasis and angiogenesis in ESCC via the HIF1alpha-mediated signaling pathway.

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