HRG/HPRG Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

HRG (Histidine Rich Glycoprotein, also known as HPRG; HRGP; THPH11), located on 3q27.3, is a Protein Coding gene. The gene produces a 59578 Da protein composed of 525 amino acids. HRG is a glycoprotein located in plasma and platelets and contains an unusually large amount of histidine and proline. It inhibits rosette formation and interacts with heparin, thrombospondin, and plasminogen. HRG binds heme, dyes, and divalent metal ions. Diseases such as Thrombophilia Due To Histidine-Rich Glycoprotein Deficiency and Thrombophilia are associated with HRG.

HRG/HPRG Protein (2)

    HRG/HPRG Antibody (7)

      HRG/HPRG ELISA Kit & Match Antibody ELISA Pair Set (2)

      HRG/HPRG cDNA Clone (28)

      NM_000412.2

      HRG/HPRG qPCR Primer (1)

      HRG/HPRG Lysate (2)

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        HRG/HPRG Background

        Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets and contains an unusually large amount of histidine and proline. In humans, five distinct domains are recognized in the mature HPRG molecule. There are two N-terminal cystatin-like modules (aa 19 - 254) and one His-Pro-rich region (aa 350 - 497) that is flanked by two Pro-rich segments (aa 276 - 321 and 498 - 525). The His-Pro-rich region contains 10 tandem repeats with an HHPHG motif, and the N- and C-termini are linked by a disulfide bond. The specific functions of HRG remain unclear, but it is known that the protein binds heme, dyes, and divalent metal ions. It inhibits rosette formation and interacts with heparin, thrombospondin, and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis, and the reduction of inhibition of coagulation indicate a potential prothrombotic effect. HPRG is evolutionarily, functionally, and structurally related to cleaved high molecular weight kininogen (HKa), an anti-angiogenic polypeptide that stimulates apoptosis of proliferating endothelial cells through binding to cell-surface tropomyosin. The antiangiogenic activity of the multidomain plasma protein HPRG is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells.

        HRG/HPRG References

        • Guan X, et al. (2004) Histidine-proline rich glycoprotein (HPRG) binds and transduces anti-angiogenic signals through cell surface tropomyosin on endothelial cells. Thromb Haemost. 92(2): 403-12.
        • Doate F, et al. (2004) Peptides derived from the histidine-proline domain of the histidine-proline-rich glycoprotein bind to tropomyosin and have antiangiogenic and antitumor activities. Cancer Res. 64(16): 5812-7.

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