HHLA2 Proteins, Antibodies, cDNA Clones Research Reagents

HHLA2 (HERV-H LTR-Associating 2, also known as B7y; B7H7; B7-H5; B7-H7), located on 3q13.13, is a Protein Coding gene. The gene produces a 46850 Da protein composed of 414 amino acids. HHLA2 encodes a protein with a secretory signal peptide, 3 immunoglobulin-like domains, and a transmembrane domain. HHLA2 belongs to the B7 family of costimulatory molecules involved in the activation and downregulation of T lymphocytes. HHLA2 binds specifically to CD28H (TMIGD2) and costimulates T cells. Diseases such as Bladder Urothelial Carcinoma are associated with HHLA2.

HHLA2 Protein (3)

    HHLA2 Antibody (1)

      HHLA2 cDNA Clone (14)


      In cloning vector

      HHLA2 Lysate (2)

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        HHLA2 Background

        B7H7 gene encodes a protein-ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. HERV–H LTR-associating 2 (HHLA2, also called B7H7/B7-H5/B7y)has been recently discovered as the newest member of the B7 family and has 23–33% similarity in amino acid sequence with the other B7 molecules. This ligand is the only B7 family member that is found in humans but not in mice. It is constitutively expressed on the surface of human monocytes and is induced on B cells. HHLA2 binds to its putative receptor(s) on a variety of immune cells including CD4 and CD8 T cells and antigen-presenting cells. Similar to B7-H3, both a T cell coinhibitory role, as well as a costimulatory role, has been reported for this ligand.

        HHLA2 References

        • Janakiram M, Chinai JM, Fineberg S, et al. Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015;21(10):2359-2366.

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