HE4 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

WFDC2 (WAP Four-Disulfide Core Domain 2) is a protein coding gene located on human chromosome 20q13.12. WFDC2 is also known as HE4, WAP5, EDDM4 and dJ461P17.6. The human WFDC2 gene encodes a 12993 Da protein containing 124 amino acids. The WFDC2 protein is biasedly expressed in salivary gland, endometrium and other tissues. WFDC2 is related to serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity. WFDC2 is associated with some diseases, including Fallopian Tube Carcinoma and Ovarian Cancer.

HE4 Protein (3)

    HE4 Antibody (10)

      HE4 ELISA Kit & Match Antibody ELISA Pair Set (2)

      HE4 cDNA Clone (41)


      In expression vector

      In lentiviral vector


      HE4 qPCR Primer (2)

      HE4 Lysate (3)

        HE4 Background

        WAP four-disulfide core domain protein 2, also known as Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2 and HE4, is a secreted protein that contains two WAP domains. WFDC2 / HE4 is a member of a family of stable 4-disulfide core proteins that are secreted at high levels. It is expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. It is highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. WFDC2 may be a component of the innate immune defences of the lung, nasal and oral cavities and suggest that WFDC2 functions in concert with related WAP domain containing proteins in epithelial host defence. WFDC2 re-expression in lung carcinomas may prove to be associated with tumour type and should be studied in further detail. Mammary gland expression of tammar WFDC2 during the course of lactation showed WFDC2 was elevated during pregnancy, reduced in early lactation and absent in mid-late lactation. WFDC2 / HE4 can undergo a complex series of alternative splicing events that can potentially yield five distinct WAP domain containing protein isoforms.

        HE4 References

        • Bingle,L. et al., 2002, Oncogene. 21 (17):2768-73.
        • Hellström,I. et al., 2003, Cancer Res. 63 (13):3695-700.
        • Bingle,L. et al., 2006, Respir Res. 7 : 61.
        • Galgano,M.T. et al., 2006, Mod Pathol.19 (6):847-53.
        • Sharp,J.A. et al., 2007, Evol Dev. 9 (4): 378-92.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.