HDAC8 Proteins, Antibodies, cDNA Clones Research Reagents

HDAC8 (Histone Deacetylase 8, also known as HD8; WTS; RPD3; CDA07; CDLS5; KDAC8; MRXS6; HDACL1), located on Xq13.1, is a Protein Coding gene. The gene produces a 41758 Da protein composed of 377 amino acids. HDAC8 is a class I HDAC. Sequence analysis predicted that the HDAC8 protein contains the 9 conserved HDAC blocks that are presumably important for catalytic function. Diseases such as Cornelia De Lange Syndrome 5 and Cornelia De Lange Syndrome 1 are associated with HDAC8. The related pathways of HDAC8 include Signaling by GPCR and Chromatin organization.

HDAC8 Protein (2)

    HDAC8 Antibody (1)

      HDAC8 cDNA Clone (30)

      HDAC8 Lysate (2)

        HDAC8 Background

        Histone deacetylase 8, also known as HDAC8 and HDACL1, is a nucleus and cytoplasm protein that belongs to the histone deacetylase family and HD type 1 subfamily. Histone deacetylases (HDACs) are a growing family of enzymes implicated in transcriptional regulation by affecting the acetylation state of core histones in the nucleus of cells. HDAC8 / HDACL1 is weakly expressed in most tissues. It is expressed at a higher level in the heart, brain, kidney, and pancreas and also in the liver, lung, placenta, prostate, and kidney. HDAC8 / HDACL1 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones ( H2A, H2B, H3, and H4 ). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC8 / HDACL1 may play a role in smooth muscle cell contractility. HDAC8 / HDACL1 may be a potential drug target for neuroblastoma differentiation therapy using selective inhibitors, avoiding unspecific side effects.

        HDAC8 References

        • Buggy JJ. et al.,2000, Biochem J. 350 (1): 199-205.
        • Krennhrubec K. et al., 2007, Bioorg Med Chem Lett. 17 (10): 2874-8.
        • Oehme I. et al., 2009, Expert Opin Investig Drugs.18 (11): 1605-17.

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