HDAC2 (Histone Deacetylase 2) is a Protein Coding gene. HDAC2 gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3, and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternative splicing results in multiple transcript variants. HDAC2 is widely expressed in testis, endometrium, and other tissues. Diseases associated with HDAC2 include Pulmonary Disease, Chronic Obstructive, and Lung Disease.