HAO1 Proteins, Antibodies, cDNA Clones Research Reagents

All HAO1 reagents are produced in house and quality controlled, including 4 HAO1 Antibody, 30 HAO1 Gene, 1 HAO1 Protein, 1 HAO1 qPCR. All HAO1 reagents are ready to use.

HAO1 Protein (1)

    HAO1 Antibody (4)

      HAO1 cDNA Clone (30)

      HAO1 qPCR Primer (1)

      More Product Popular With Customers

      HAO1 Background

      Hydroxyacid oxidase 1, also known as Glycolate oxidase, HAO1 and GOX1, is a member of the FMN-dependent alpha-hydroxy acid dehydrogenase family. HAO1 / GOX1 has 2-hydroxyacid oxidase activity. It is most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. HAO1 / GOX1 is a liver-specific peroxisomal enzyme that oxidizes glycolate to glyoxylate with concomitant production of H2O2. In Hao1 messenger RNA (mRNA), an iron-responsive element (IRE) homologous to the sequence recognized by iron regulatory proteins (IRP), key regulators of iron homeostasis, is present. Mammalian HAO1 / GOX1 is a peroxisomal protein and that the C-terminal sequence SKI acts as the targeting signal. Down-regulation of HAO1 / GOX1 expression during oxidative stress may provide a mechanism to prevent excessive H2O2 formation in liver peroxisomes and may represent the prototype of a poorly recognized but potentially relevant response to oxidative injury involving down-regulation of ROS-producing enzymes.

      HAO1 References

      • Jones J.M.et al., 2000, J. Biol. Chem. 275:12590-7.
      • Recalcati,S. et al., 2001, J Cell Sci. 114 (Pt 9):1625-9.
      • Recalcati,S. et al., 2003, Hepatology. 38 (5):1159-66.
      • Murray M.S.et al., 2008, Biochemistry 47:2439-49.
      • Bourhis J.M.et al., 2009, Acta Crystallogr. F 65:1246-53.

      Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.