Granzyme B Proteins, Antibodies, cDNA Clones Research Reagents

All Granzyme B reagents are produced in house and quality controlled, including 6 Granzyme B Antibody, 43 Granzyme B Gene, 1 Granzyme B IP Kit, 1 Granzyme B Lysate, 1 Granzyme B Protein, 2 Granzyme B qPCR. All Granzyme B reagents are ready to use.

Granzyme B Protein (1)

    Granzyme B Antibody (6)

      Granzyme B cDNA Clone (43)

      Granzyme B Lysate (1)

        Granzyme B Background

        Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of GZMB have been identified including the key substrate caspase-3, ICAD and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells, and accordingly plays an essential role in immunosurveillance.

        Granzyme B References

        • Schmid J., et al.,(1987), Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes. J. Immunol. 139:250-256.
        • Caputo A., et al., (1988), Structure and differential mechanisms of regulation of expression of a serine esterase gene in activated human T lymphocytes.J. Biol. Chem. 263:6363-6369.
        • Trapani J.A., et al.,(1988), Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes.Proc. Natl. Acad. Sci. U.S.A. 85:6924-6928.

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