GBP1 Proteins, Antibodies, cDNA Clones Research Reagents

All GBP1 reagents are produced in house and quality controlled, including 1 GBP1 Antibody, 1 GBP1 Gene, 1 GBP1 Lysate, 1 GBP1 Protein. All GBP1 reagents are ready to use.

GBP1 Protein (1)

    GBP1 Antibody (1)

      GBP1 cDNA Clone (1)

      NM_002053.2

      In expression vector

      GBP1 Lysate (1)

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        GBP1 Background

        Guanylate-binding protein 1 (GBP-1) is a member of the GBP family whose members are GTPases induced in response to interferon-λ (IFN-λ), with seven highly homologous members in humans, termed HuGBP-1 to HuGBP-7. GBP-1 expression is induced by type1 and type2 interferons, including IFN-λ and also by interleukin-1β (IL-1β), IL-1α, and tumor necrosis factor-α (TNF-α). GBP-1 is key to the protective immunity against microbial and viral pathogens. GBP-1 was only secreted from endothelial cells. Secretion occurred without the presence of a leader peptide. Secretion procession is a nonclassical, likely ABC transporter-dependent, pathway and independent of GBP-1 GTPase activity and isoprenylation, and did not require additional interferon-λ-induced factors. Clinically most important was the detection of significantly increased GBP-1 concentrations in the cerebrospinal fluid of patients with bacterial meningitis as compared to control patients.

        GBP1 References

        • Tripal P, et al. (2007) Unique features of different members of the human guanylate-binding protein family. J Interferon Cytokine Res. 27(1): 44-52.
        • Naschberger E, et al. (2006) Human Guanylate Binding Protein-1 Is a Secreted GTPase Present in Increased Concentrations in the Cerebrospinal Fluid of Patients with Bacterial Meningitis. Am J Pathol. 169(3): 1088-99.

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