Fragilis/IFITM3 Proteins, cDNA Clones Research Reagents

IFITM3 (Interferon Induced Transmembrane Protein 3, also known as 1-8U; IP15; DSPA2b), located on 11p15.5, is a Protein Coding gene. The gene produces a 14632 Da protein composed of 133 amino acids. IFITM3 is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. The IFITM3 protein is approximately 90% identical to IFITM2, has an N-terminal signal sequence, 3 potential phosphorylation sites, and a C-terminal leucine zipper.

Fragilis/IFITM3 Protein (1)

    Fragilis/IFITM3 cDNA Clone (42)

    NM_021034.2
    BC006794

    In lentiviral vector

    NM_001136124.1

    Fragilis/IFITM3 Lysate (1)

      Fragilis/IFITM3 Background

      Interferon-induced transmembrane protein 3 (IFITM3) belongs to the CD225 family. To replicate, viruses must gain access to the host cell's resources. Interferon (IFN) regulates the actions of a large complement of interferon effector genes (IEGs) that prevent viral replication. The interferon-inducible transmembrane protein family members, IFITM1, 2, and 3, are IEGs required for inhibition of influenza A virus, dengue virus, and West Nile virus replication in vitro. IFITM3 is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. It is both necessary and sufficient for preventing the emergence of viral genomes from the endosomal pathway. Viral pseudo particles were inhibited from transferring their contents into the host cell cytosol by IFN, and IFITM3 was required and sufficient for this action. IFITM3 overexpression is sufficient for this phenotype. Moreover, IFITM3 partially resides in late endosomal and lysosomal structures, placing it in the path of invading viruses.

      Fragilis/IFITM3 References

      • Tanaka SS, et al. (2005) IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Dev Cell. 9(6):745-56.
      • Li D, et al. (2011) KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesis. Clin Cancer Res. 17(11):3558-68.
      • Lu J, et al. (2011) The IFITM proteins inhibit HIV-1 infection. J Virol. 85(5):2126-37.

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