FOXO1 Antibodies, cDNA Clones Research Reagents

FOXO1 (Forkhead Box O1, also known as FKH1; FKHR; FOXO1A), located on 13q14.11, is a Protein Coding gene. This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The encoded protein is a downstream target of AKT and plays crucial roles in cell cycle control, apoptosis, metabolism, and adipocyte differentiation. It is currently believed that FOXO1 translocation between nuclei and cytoplasm is involved in the regulation of FOXO1 activity, thus affecting adipocyte differentiation.

FOXO1 Antibody (1)

    FOXO1 cDNA Clone (2)

    NM_019739.3

    In cloning vector

    In lentiviral vector

    More Product Popular With Customers

    FOXO1 Background

    FOXO1 transcription factors affect some cell types that are important in the host response. Cell types whose functions are modulated by FOXO1 include keratinocytes in the skin and mucosal dermis, neutrophils and macrophages, dendritic cells, Tregs, and B-cells. Forkhead box-O1 (FOXO1) is a downstream target of AKT and plays crucial roles in cell cycle control, apoptosis, metabolism, and adipocyte differentiation. It is thought that FOXO1 affects adipocyte differentiation by regulating lipogenesis and cell cycle. With the deepening in the understanding of this field, it is currently believed that FOXO1 translocation between nuclei and cytoplasm is involved in the regulation of FOXO1 activity, thus affecting adipocyte differentiation. FOXO1 is activated by bacterial or cytokine stimulation. Its translocation to the nucleus and binding to promoter regions of genes that have FOXO response elements is stimulated by the MAP kinase pathway and inhibited by the PI3 kinase/AKT pathway.

    FOXO1 References

    • Graves DT, et al. (2019) Mucosal immunity and the foxo1 transcription factors. Front Immunol 10 2530.
    • Chen J, et al. (2019) Molecular mechanisms of foxo1 in adipocyte differentiation. J Mol Endocrinol 62 (3): R239-r253.
    • Cabrera-Ortega AA, et al. (2017) The role of forkhead box 1 (foxo1) in the immune system: Dendritic cells, t cells, b cells, and hematopoietic stem cells. Crit Rev Immunol 37 (1): 1-13.

    Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.