ficolin 1/FCN1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All ficolin 1/FCN1 reagents are produced in house and quality controlled, including 8 ficolin 1/FCN1 Antibody, 1 ficolin 1/FCN1 ELISA, 26 ficolin 1/FCN1 Gene, 2 ficolin 1/FCN1 Lysate, 2 ficolin 1/FCN1 Protein, 2 ficolin 1/FCN1 qPCR. All ficolin 1/FCN1 reagents are ready to use.

ficolin 1/FCN1 Protein (2)

    ficolin 1/FCN1 Antibody (8)

      ficolin 1/FCN1 ELISA Kit & Match Antibody ELISA Pair Set (1)

      ficolin 1/FCN1 cDNA Clone (26)

      NM_002003.2
      XM_001098002.2

      ficolin 1/FCN1 Lysate (2)

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        ficolin 1/FCN1 Background

        Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. The Ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. Three Ficolins have been identified in humans: L-Ficolin, H-Ficolin and M-Ficolin (also referred to as Ficolin-2, -3 and -1, respectively). They are soluble oligomeric defence proteins with lectin-like activity and they are structurally similar to the human collectins, mannan-binding lectin (MBL) and surfactant protein A and D. Dysfunction or abnormal expressions of Ficolins may involved in the pathogenesis of human diseases including infectious and inflammatory diseases, autoimmune disease and clinical syndrome of preeclampsia. They are soluble oligomeric defence proteins with lectin-like activity and they are structurally similar to the human collectins, mannan-binding lectin (MBL) and surfactant protein A and D. Upon recognition of the infectious agent, the Ficolins act through two distinct routes: initiate the lectin pathway of complement activation through attached serine proteases (MASPs), and a primitive opsonophagocytosis thus limiting the infection and concurrently orchestrating the subsequent adaptive clonal immune response. Ficolin-1 (FCN1) is predominantly expressed in the peripheral blood leukocytes.

        ficolin 1/FCN1 References

        • Thiel S. (2007) Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins. Mol Immunol. 44(16): 3875-88.
        • Zhang XL, et al. (2008) Ficolins: structure, function and associated diseases. Adv Exp Med Biol. 632: 105-15.
        • Garred P, et al. (2009) MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement. Mol Immunol. 46(14): 2737-44.

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