Ephrin-A1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All Ephrin-A1 reagents are produced in house and quality controlled, including 9 Ephrin-A1 Antibody, 2 Ephrin-A1 ELISA, 27 Ephrin-A1 Gene, 5 Ephrin-A1 Lysate, 6 Ephrin-A1 Protein, 2 Ephrin-A1 qPCR. All Ephrin-A1 reagents are ready to use.

Ephrin-A1 Protein (6)

    Ephrin-A1 Antibody (9)

      Ephrin-A1 ELISA Kit & Match Antibody ELISA Pair Set (2)

      Ephrin-A1 cDNA Clone (27)

      NM_004428.2
      NM_010107.4

      In cloning vector

      NM_053599.2

      Ephrin-A1 Lysate (5)

        Ephrin-A1 Background

        EPH-related receptor tyrosine kinase ligand 1 (abbreviated as Ephrin-A1) also known as ligand of eph-related kinase 1 or EFNA1, is a member of the ephrin (EPH) family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin-A1/EFNA1 and its Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. Ephrin-A1 and one of its receptor EphA2 were expressed in xenograft endothelial cells and also tumor cells and play a role in human cancers, at least in part by influencing tumor neovascularization.

        Ephrin-A1 References

        • Deroanne C, et al. (2003) EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. J Cell Sci. 116(7): 1367-76.
        • Ojima T, et al. (2006) EphrinA1 inhibits vascular endothelial growth factor-induced intracellular signaling and suppresses retinal neovascularization and blood-retinal barrier breakdown. Am J Pathol. 168(1): 331-9.
        • Wu D, et al. (2004) Prognostic value of EphA2 and EphrinA-1 in squamous cell cervical carcinoma. Gynecol Oncol. 94(2): 312-9.

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