ECSIT Proteins, Antibodies, cDNA Clones Research Reagents

All ECSIT reagents are produced in house and quality controlled, including 2 ECSIT Antibody, 30 ECSIT Gene, 1 ECSIT Protein, 2 ECSIT qPCR. All ECSIT reagents are ready to use.

ECSIT Protein (1)

    ECSIT Antibody (2)

      ECSIT cDNA Clone (30)

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      ECSIT Background

      ECSIT is an adapter protein of the toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT is specific for the Toll/IL-1 pathways and is a regulator of MEKK-1 processing. It bridges TRAF6 to MEKK-1. Expression of wild-type ECSIT accelerates processing of MEKK-1, whereas a dominant-negative fragment of ECSIT blocks MEKK-1 processing and activation of NF-kappaB. ECSIT is also required for normal embryonic development and efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.

      ECSIT References

      • Kopp E. et al., 1999, Genes Dev. 13 (16): 2059-71.
      • The MGC Project Team. 2004, Genome Res. 14: 2121-7.
      • Vogel RO. et al., 2007, Genes Dev. 21: 615-24.

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