DR6 Proteins, Antibodies, cDNA Clones Research Reagents

TNFRSF21 (TNF Receptor Superfamily Member 21) is a protein coding gene located on human chromosome 6p12.3. TNFRSF21 is also known as DR6, CD358 and BM-018. The human TNFRSF21 gene encodes a 71845 Da protein containing 655 amino acids. The TNFRSF21 protein is broadly expressed in urinary bladder, fat and other tissues. Among its related pathways are Apoptosis Modulation and Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. TNFRSF11B is an important paralog of TNFRSF21 gene. TNFRSF21 is associated with some diseases, including Diffuse Infiltrative Lymphocytosis Syndrome and Juvenile Ankylosing Spondylitis.

DR6 Protein (6)

    DR6 Antibody (6)

      DR6 cDNA Clone (52)


      DR6 Lysate (6)

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        DR6 Background

        TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.

        DR6 References

        • Pan G, et al. (1998) Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 431(3): 351-6.
        • Benschop R, et al. (2009) Tumor necrosis factor receptor superfamily member 21: TNFR-related death receptor-6, DR6. Adv Exp Med Biol. 647: 186-94.
        • Klma M, et al. (2009) Functional analysis of the posttranslational modifications of the death receptor 6. Biochim Biophys Acta. 1793(10): 1579-87.

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