DEP-1 Proteins, Antibodies Research Reagents

PTPRJ (Protein Tyrosine Phosphatase Receptor Type J) is a protein coding gene located on human chromosome 11p11.2. PTPRJ is also known as DEP1, SCC1, CD148, HPTPeta, and R-PTP-ETA. The human PTPRJ gene encodes a 145941 Da protein containing 1337 amino acids. The PTPRJ protein is broadly expressed in thyroid, appendix and other tissues. Among its related pathways are Signaling by GPCR and Development HGF signaling pathway. PTPRJ is related to protein kinase binding and protein tyrosine phosphatase activity. PTPRB is an important paralog of PTPRJ gene. PTPRJ is associated with some diseases, including Colorectal Cancer and Cogan Syndrome.

DEP-1 Protein (1)

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      DEP-1 qPCR Primer (1)

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      DEP-1 Background

      DEP1 / PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. DEP1 / PTPRJ possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. DEP1 / PTPRJ is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. In stable MCF-7 cell lines, induction of DEP-1 expression inhibited breast cancer cell growth by 5-10-fold. These data describe PTPs expressed and regulated in breast cancer cell lines during differentiation and identify one PTP, DEP-1, that inhibits the growth of breast cancer cells in vitro.

      DEP-1 References

      • Holsinger LJ, et al. (2002) The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120. Oncogene. 21(46): 7067-76.
      • Huang X, et al. (2009) Natural variation at the DEP1 locus enhances grain yield in rice. Nat Genet. 41(4): 494-7.
      • Kuramochi S, et al. (1996) Molecular cloning and characterization of Byp, a murine receptor-type tyrosine phosphatase similar to human DEP-1. FEBS Lett. 378(1): 7-14.

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