DcR3 Proteins, Antibodies, cDNA Clones Research Reagents

TNFRSF6B (TNF Receptor Superfamily Member 6b) is a protein coding gene located on human chromosome 20q13.33. TNFRSF6B is also known as M68, TR6, DCR3, M68E, and DJ583P15.1.1. The human TNFRSF6B gene encodes a 32680 Da protein containing 300 amino acids. The TNFRSF6B protein is broadly expressed in appendix, spleen and other tissues. Among its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and TNFR1 Pathway. TNFRSF11B is an important paralog of TNFRSF6B gene. TNFRSF6B is associated with some diseases, including Dyskeratosis Congenita, Autosomal Recessive 5 and Dyskeratosis Congenita Autosomal Recessive.

DcR3 Protein (1)

    DcR3 Antibody (1)

      DcR3 cDNA Clone (13)


      DcR3 qPCR Primer (1)

      DcR3 Lysate (1)

        DcR3 Background

        Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) also known as DcR3(Decoy Receptor 3) and M68 is the tumor necrosis factor receptor superfamily. DcR3/TNFRSF6B belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. DcR3/TNFRSF6B is detected in fetal lung, brain and liver. DcR3/TNFRSF6B is also detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. This protein is highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

        DcR3 References

        • Migone TS, et al. (2002) TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity. 16(3): 479-92.
        • Takahama Y, et al. (2002) The prognostic significance of overexpression of the decoy receptor for Fas ligand (DcR3) in patients with gastric carcinomas. Gastric Cancer. 5(2): 61-8.
        • Zhang J, et al. (2001) Modulation of T-cell responses to alloantigens by TR6/DcR3. J Clin Invest. 107(11): 1459-68.

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