DcR1/TRAILR3 Proteins, Antibodies, cDNA Clones Research Reagents

TNFRSF10C (TNF Receptor Superfamily Member 10c) is a protein coding gene located on human chromosome 8p21.3. TNFRSF10C is also known as LIT, DCR1, TRID, CD263, TRAILR3, TRAIL-R3 and DCR1-TNFR. The human TNFRSF10C gene encodes a 27407 Da protein containing 259 amino acids. The TNFRSF10C protein is broadly expressed in appendix, bone marrow and other tissues. Among its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and TP53 Regulates Transcription of Cell Death Genes. TNFRSF10C is related to transmembrane signaling receptor activity and TRAIL binding. TNFRSF10D is an important paralog of TNFRSF10C gene. TNFRSF10C is associated with some diseases, including Epithelial-Stromal Tgfbi Dystrophy and Stone In Bladder Diverticulum.

DcR1/TRAILR3 Protein (1)

    DcR1/TRAILR3 Antibody (7)

      DcR1/TRAILR3 cDNA Clone (13)


      DcR1/TRAILR3 qPCR Primer (1)

      DcR1/TRAILR3 Lysate (1)

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        DcR1/TRAILR3 Background

        TNFRSF10C CNV in patients with CRC is associated with distant metastatic disease. A high frequency of CGI methylation in the TNFRSF10C promoter results in inactivation of the gene and enhancement of tumor growth in most PC cell lines (except CFPAC-1). Inactivation of TNFRSF10C by CpG island (CGI) hypermethylation can play an important role in PC progression and be potentially useful as a diagnostic marker and a new therapeutic approach for PC.

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