DAPK1 Proteins, cDNA Clones Research Reagents

All DAPK1 reagents are produced in house and quality controlled, including 2 DAPK1 Gene, 1 DAPK1 Lysate, 1 DAPK1 Protein, 1 DAPK1 qPCR. All DAPK1 reagents are ready to use.

DAPK1 Protein (1)

    DAPK1 cDNA Clone (2)


    In expression vector

    In lentiviral vector

    DAPK1 qPCR Primer (1)

    DAPK1 Lysate (1)

      DAPK1 Background

      Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK1 contains tenANK repeats, onedeath domain and oneprotein kinase domain. DAPK1 is a calcium / calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis. DAPK1 gene is a candidate tumor suppressor (TSG) and the abnormal methylation of DAPK1 gene has been found in many carcinomas. DAPK1 over-expression can induce cell apoptosis and inhibit tumor cell metastasis. DAPK1 gene over-expression could suppress PGCl3 cells malignant phenotype, inhibit PGCl3 cells growth, invasive, migration and adhesion ability, upregulate p53 gene and downregulate bcl-2 gene. Loss of activity of death-associated protein kinase 1 ( DAPK1 ) may be an independent factor affecting survival of non-small cell lung cancer patients. DAPK1 promoter methylation might play a significant role in the progression of chronic myeloid leukemia ( CML ).

      DAPK1 References

      • Zhang,H.T. et al., 2004, Ai Zheng. 23 (5):497-501.
      • Martoriati,A. et al., 2005, Oncogene. 24 (8):1461-6.
      • Li,Y. et al., 2006, Hum Mol Genet. 15 (17): 2560-8.
      • Martinez-Glez,V. et al., 2007, Neoplasma. 54 (2):123-6.
      • Raval,A. et al., 2007, Cell. 129 (5):879-90.
      • Gade,P. et al., 2009, Int J Cancer. 125 (7):1566-74.

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