Cyclophilin B Proteins, Antibodies, cDNA Clones Research Reagents

PPIB (Peptidylprolyl Isomerase B) is a protein coding gene located on human chromosome 15q22.31. PPIB is also known as OI9, CYPB, SCYLP, CYP-S1, HEL-S-39 and. The human PPIB gene encodes a 23743 Da protein containing 216 amino acids. The PPIB protein is ubiquitously expressed in thyroid, placenta and other tissues. Among its related pathways are Immune response Lectin induced complement pathway and Degradation of the extracellular matrix. PPIB is related to unfolded protein binding. PPIC is an important paralog of PPIB gene. PPIB is associated with some diseases, including Osteogenesis Imperfecta, Type Ix and Osteogenesis Imperfecta, Type Ii.

Cyclophilin B Protein (1)

    Cyclophilin B Antibody (2)

      Cyclophilin B cDNA Clone (39)


      Cyclophilin B Lysate (1)

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        Cyclophilin B Background

        PPIB is identified as a candidate gene for OI-IX. Osteogenesis imperfecta (OI) is an inherited disorder of connective tissue typically caused by defects in either COL1A1 or COL1A2. A number of other genes causative of this disorder have been found, including PPIB, which forms one subunit of the prolyl 3-hydroxylase enzyme complex. Patients with OI caused by PPIB mutation should have appropriate early and regular management of their hearing.

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