Cyclophilin A Proteins, Antibodies, cDNA Clones Research Reagents

PPIA (Peptidylprolyl Isomerase A) is a protein coding gene located on human chromosome 7p13. PPIA is also known as CYPA, CYPH and HEL-S-69p. The human PPIA gene encodes a 18012 Da protein containing 165 amino acids. The PPIA protein is ubiquitously expressed in lymph node, colon and other tissues. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. PPIA is related to peptide binding. PPIAL4C is an important paralog of PPIA gene. PPIA is associated with some diseases, including Hordeolum Externum and Alzheimer Disease 11.

Cyclophilin A Protein (2)

    Cyclophilin A Antibody (5)

      Cyclophilin A cDNA Clone (58)

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      Cyclophilin A Background

      Peptidyl-prolyl cis-trans isomerase A, also known as PPIase A, Rotamase A, Cyclophilin A, Cyclosporin A-binding protein, PPIA and CYPA, is a cytoplasm protein that belongs to the cyclophilin-type PPIase family and PPIase A subfamily. Cyclophilins (CyPs) are a family of proteins found in organisms ranging from prokaryotes to humans. These molecules exhibit peptidyl-prolyl isomerase activity, suggesting that they influence the conformation of proteins in cells. PPIA / Cyclophilin A accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIA / Cyclophilin A is secreted by vascular smooth muscle cells in response to inflammatory stimuli, and could thus contribute to atherosclerosis. It is not essential for mammalian cell viability. PPIA / Cyclophilin A can interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions.

      Cyclophilin A References

      • Haendler B., et al.,(1987), Complementary DNA for human T-cell cyclophilin. EMBO J. 6:947-950.
      • Haendler B., et al., (1990), Characterization of the human cyclophilin gene and of related processed pseudogenes.Eur. J. Biochem. 190:477-482.
      • Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.

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