Cx3cr1 Antibodies, cDNA Clones Research Reagents

All Cx3cr1 reagents are produced in house and quality controlled, including 1 Cx3cr1 Antibody, 5 Cx3cr1 Gene. All Cx3cr1 reagents are ready to use.

Cx3cr1 Antibody (1)

    Cx3cr1 cDNA Clone (5)

    NM_001171174.1

    In expression vector

    In lentiviral vector

    NM_009987.3

    In expression vector

    In lentiviral vector

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    Cx3cr1 Background

    The CX3C chemokine axis consists of fractalkine (CX3CL1) and its receptor (CX3CR1); these are expressed by neurons and microglia respectively, and are known to modulate microglial activation. Neuronal Cx3cr1 may impact Alzheimer's disease-like pathology by modulating conformational state-dependent amyloid-beta-induced synaptotoxicity. Microglial cells participate in brain development and influence neuronal loss and synaptic maturation. Fractalkine is an important neuronal chemokine whose expression increases during development and that can influence microglia function via the fractalkine receptor, CX3CR1. Mice lacking Cx3cr1 show a variety of neuronal defects thought to be the result of deficient microglia function. Knockout of the microglial chemokine receptor Cx3cr1 to prevent neuron loss.

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