CTLA-4 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All CTLA-4 reagents are produced in house and quality controlled, including 18 CTLA-4 Antibody, 1 CTLA-4 ELISA, 31 CTLA-4 Gene, 1 CTLA-4 IP Kit, 14 CTLA-4 Lysate, 17 CTLA-4 Protein, 2 CTLA-4 qPCR. All CTLA-4 reagents are ready to use.

CTLA-4 Protein (17)

CTLA-4 Antibody (18)

    CTLA-4 ELISA Kit & Match Antibody ELISA Pair Set (1)

    CTLA-4 cDNA Clone (31)


    In cloning vector


    In cloning vector


    In cloning vector

    In expression vector

    In lentiviral vector

    CTLA-4 Lysate (14)

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      CTLA-4 Background

      Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).

      CTLA-4 References

      • Slavik JM, et al. (1999) CD28/CTLA-4 and CD80/CD86 families: signaling and function. Immunol Res. 19(1): 1-24.
      • Holmberg D, et al. (2005) CTLA-4 (CD152) and its involvement in autoimmune disease. Autoimmunity. 38(3): 225-33.
      • Chin LT, et al. (2008) Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases. Chang Gung Med J. 31(1): 1-15.

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