Cofilin Proteins, Antibodies, cDNA Clones Research Reagents

All Cofilin reagents are produced in house and quality controlled, including 2 Cofilin Antibody, 62 Cofilin Gene, 1 Cofilin Protein, 2 Cofilin qPCR. All Cofilin reagents are ready to use.

Cofilin Protein (1)

    Cofilin Antibody (2)

      Cofilin cDNA Clone (62)

      NM_017147.2

      In cloning vector

      In lentiviral vector

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      Cofilin Background

      CFL1, also known as n-cofilin, is a member of the ADF/Cofilin family. This family comprises three genes: CFL1, CFL2 and DSTN (destrin). ADF/Cofilin family members bind G-actin monomers and depolymerize actin filaments through two mechanisms: severing and increasing the off-rate for actin monomers from the pointed end. Cofilin also binds with other proteins such as myosin, tropomyosin, α-actinin, gelsolin and scruin. These proteins compete with cofilin for actin binding. Сofilin also plays a role in innate immune response. CFL1 contains 1 ADF-H domain and is widely distributed in various tissues. It is important for normal progress through mitosis and normal cytokinesis.

      Cofilin References

      • Lappalainen P. et al., 1997, Nature. 388 (6637): 78-82.
      • Ichetovkin I. et al., 2000, Cell Motil. 45 (4): 293-306.
      • Carlier MF. et al., 1997, J Cell Biol. 136 (6): 1307-22.

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