CES3 Antibodies, cDNA Clones Research Reagents

All CES3 reagents are produced in house and quality controlled, including 5 CES3 Antibody, 13 CES3 Gene, 1 CES3 qPCR. All CES3 reagents are ready to use.

CES3 Antibody (5)

    CES3 cDNA Clone (13)

    NM_024922.4

    CES3 qPCR Primer (1)

    CES3 Background

    Carboxylesterases hydrolyze esters of short-chain fatty acids and have roles in animals ranging from signal transduction to xenobiotic detoxification. In enzymology, a carboxylesterase is an enzyme that catalyzes the chemical reaction: a carboxylic ester + H2O = an alcohol + a carboxylate. Most enzymes from this group belong to the superfamily of hydrolases with alpha/beta protein fold (so called Alpha/beta hydrolase fold), specifically those acting on carboxylic ester bonds. The carboxylesterase family of evolutionarily related proteins (those with clear sequence homology to each other) includes a number of proteins with different substrate specificities, such as acetylcholinesterases. Carboxylesterase 3, also known as Liver carboxylesterase 31 homolog and CES3, is a endoplasmic reticulum lumen which belongs to thetype-B carboxylesterase/lipase family. CES3 is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. CES3 shows low catalytic efficiency for hydrolysis of CPT-11, a prodrug for camptothecin used in cancer therapeutics. CES3 is expressed in liver, colon and small intestine.

    CES3 References

    • Augusteyn RC. et al.,1969, Biochim Biophys Acta. 171 (1): 128-37.
    • Saito S. et al., 2003, J. Hum. Genet. 48: 249-70.
    • Sanghani SP. et al., 2003, Clin Cancer Res. 9: 4983-91.
    • Sanghani SP. et al., 2004, Drug Metab Dispos. 32: 505-11.
    • Chen R. et al., 2009, J Proteome Res. 8: 651-61.

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