CDX2 is a transcription factor that acts as a tumor suppressor in colorectal cancer (CRC). CDX2 is a homeobox gene encoding transcriptional factors for intestinal organogenesis and represents a specific marker of colorectal adenocarcinoma (CRC) differentiation.Its loss triggers metastatic process and tumor progression. CDX2 stimulates porcine intestinal epithelial cell proliferation by activating the mTORC1 and Wnt/beta-catenin signaling pathways. Overexpression of CDX2 is a reliable biomarker of a better prognosis in solid malignancies. Caudal-related homeobox transcription factor 2 (CDX2) has recently been proposed as a prognostic factor for gastric carcinoma.