CD45-IHC抗体

产品编号 100342-R145
抗体名称 CD45抗体
免疫原 A synthetic peptide corresponding to the C-terminus of the Human CD45 / PTPRC (Catalog:50713-M02H1,义翘神州)
克隆号  
Ig类型 兔-IgG
克隆类型 多克隆抗体
应用 IHC-P稀释倍数 1:100-500
特异性 Human CD45 / PTPRC

CD45-IHC抗体多组织验证图

阳性组织

阴性组织

阳性组织 扁桃体、结肠、阑尾、脾脏、肾脏、小肠、胰腺癌、淋巴癌、恶黑、肺癌
阴性组织 骨骼肌、前列腺癌、神经瘤

CD45-IHC抗原介绍

抗原名称 CD45(白细胞共同抗原)
背景介绍 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008].
表达信息 可表达于所有白细胞、白细胞前体细胞,且和抗体结合后无明显内在化表现。
细胞定位 细胞膜
结构特征 由两条相同肽链组成的同源二聚体,编码基因定位于1号染色体长臂。编码的跨膜蛋白产物可分为胞浆区、跨膜区、膜外区三个结构域
功能 在T细胞受体、B 细胞受体信号传导中发挥重要作用,并参与调节淋巴细胞的发育分化。在造血细胞的生长发育、活化及凋亡过程中担负重要的调控作用
研究领域 细胞生物  免疫学  神经生物学  信号转导  干细胞  转录调节因子  细胞表面分子  糖蛋白  细胞类型标志物  自然杀伤细胞  淋巴细胞  T-淋巴细胞  B-淋巴细胞  细胞膜蛋白 

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