CD45 Proteins, Antibodies, cDNA Clones Research Reagents

PTPRC (Protein Tyrosine Phosphatase Receptor Type C) is a protein coding gene located on human chromosome 1q31.3-q32.1. PTPRC is also known as LCA, LY5, B220, CD45, L-CA, T200, CD45R and GP180. The human PTPRC gene encodes a 147486 Da protein containing 1306 amino acids. The PTPRC protein is biasedly expressed in lymph node, appendix and other tissues. Among its related pathways are B cell receptor signaling pathway (KEGG) and Activation of cAMP-Dependent PKA. PTPRC is related to protein kinase binding and phosphatase activity. PTPRT is an important paralog of PTPRC gene. PTPRC is associated with some diseases, including Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive and Hepatitis C Virus.

CD45 Protein (6)

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      CD45 cDNA Clone (54)


      CD45 Lysate (6)

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        CD45 Background

        The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. CD45 is found expression specifically in hemotopietic cells. CD45 consists of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It serves as an essential regulator of T-cell and B-cell antigen receptor signaling through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling and it also can suppress JAK kinases.

        CD45 References

        • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
        • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
        • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
        • Irie-Sasaki J, et al. (2001) CD45 is a JAK phosphatase and negatively regulates cytokine receptor signaling. Nature. 409: 349-54.

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