CD31 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) is a protein coding gene located on human chromosome 17q23.3. PECAM1 is also known as CD31, PECA1, GPIIA', PECAM-1, endoCAM and CD31/EndoCAM. The human PECAM1 gene encodes an 82522 Da protein containing 738 amino acids. The PECAM1 protein is broadly expressed in placenta, lung and other tissues. Among its related pathways are Degradation of the extracellular matrix and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling. FCRL5 is an important paralog of PECAM1 gene. PECAM1 is associated with some diseases, including Angiosarcoma and Capillary Hemangioma.

CD31 Protein (4)

    CD31 Antibody (28)

      CD31 ELISA Kit & Match Antibody ELISA Pair Set (2)

      CD31 cDNA Clone (53)


      In expression vector


      CD31 Lysate (4)

        CD31 Background

        The Cluster of Differentiation 31 (CD31) adhesion molecule, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1), is the only known member of the CAM family on platelets. CD31 protein is a 130-kDa transmembrane glycoprotein expressed by endothelial cells, platelets, monocytes, neutrophils, and certain T cell subsets. CD31 protein is also expressed in certain tumors, including epithelioid hemangioendothelioma, other vascular tumors, and histiocytic malignancies. CD31 plays a key role in removing aged neutrophils and tissue regeneration. CD31 protein mediates the homotypic or heterotypic cell adhesion by binding to itself or the leukocyte integrin αvβ3, and thus plays a role in neutrophil recruitment in inflammatory responses, transendothelial migration of leukocytes, as well as in cardiovascular development.

        CD31 References

        • Deaglio S, et al. (2000) CD38/CD31, a receptor/ligand system ruling adhesion and signaling in human leukocytes. Chem Immunol. 75: 99-120.
        • Kohler S, et al. (2009) Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets. Blood. 113(4): 769-74.

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