CD3 epsilon/CD3e Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All CD3 epsilon/CD3e reagents are produced in house and quality controlled, including 18 CD3 epsilon/CD3e Antibody, 1 CD3 epsilon/CD3e ELISA, 69 CD3 epsilon/CD3e Gene, 2 CD3 epsilon/CD3e IP Kit, 11 CD3 epsilon/CD3e Lysate, 12 CD3 epsilon/CD3e Protein, 2 CD3 epsilon/CD3e qPCR. All CD3 epsilon/CD3e reagents are ready to use.

All CD3 epsilon/CD3e Reagents

CD3 epsilon/CD3e Protein (12)

    CD3 epsilon/CD3e Antibody (18)

      CD3 epsilon/CD3e ELISA Kit & Match Antibody ELISA Pair Set (1)

      CD3 epsilon/CD3e cDNA Clone (69)


      In cloning vector

      In lentiviral vector


      In cloning vector

      In expression vector


      CD3 epsilon/CD3e Lysate (11)

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        CD3 epsilon/CD3e Background

        T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. In the CD3 epsilon mutant mice, all stages of T cell development and activation that are TCR-dependent were impaired, but not eliminated, including activation of mature naïve T cells with the MHCII presented superantigen, staphylococcal enterotoxin B, or with a strong TCR cross-linking antibody specific for either TCR-Cbeta or CD3 epsilon. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.

        CD3 epsilon/CD3e References

        • Fischer A, et al. (2005) CD3 deficiencies. Curr Opin Allergy Clin Immunol. 5(6): 491-5.
        • Wang Y, et al. (2009) A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling. PLoS Biol. 7(12): e1000253.
        • Martnez-Martn N, et al. (2009) Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3epsilon. Sci Signal. 2(83): ra43.
        • Deford-Watts LM, et al. (2009) The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions. J Immunol. 183(2): 1055-64.

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