CD155/PVR Proteins, Antibodies, cDNA Clones Research Reagents

PVR (PVR Cell Adhesion Molecule) is a protein coding gene located on human chromosome 19q13.31. PVR is also known as PVS, HVED, CD155, NECL5, TAGE4 and Necl-5. The human PVR gene encodes a 45303 Da protein containing 417 amino acids. The PVR protein is ubiquitously expressed in adrenal, placenta and other tissues. Among its related pathways are Cell junction organization and Innate Immune System. PVR is related to virus receptor activity. NECTIN2 is an important paralog of PVR gene. PVR is associated with some diseases, including Poliomyelitis and Paralytic Poliomyelitis.

CD155/PVR Protein (13)

    CD155/PVR Antibody (24)

      CD155/PVR cDNA Clone (67)

      NM_001135768.1
      NM_006505.3
      NM_001135770.3

      In expression vector

      In lentiviral vector

      NM_027514.1
      NM_017076.2
      NM_001043386.1

      CD155/PVR Lysate (9)

        CD155/PVR Background

        CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhesion, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.

        CD155/PVR References

        • Freistadt MS, et al. (2000) Hematopoietic cells from CD155-transgenic mice express CD155 and support poliovirus replication ex vivo. Microb Pathog. 29(4): 203-12.
        • Sato T, et al. (2004) Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin- and cadherin-based adherens junctions. Genes Cells. 9(9): 791-9.
        • Kakunaga S, et al. (2004) Enhancement of serum- and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/poliovirus receptor/CD155 through the Ras-Raf-MEK-ERK signaling. J Biol Chem. 279(35): 36419-25.
        • Sato T, et al. (2005) Common signaling pathway is used by the trans-interaction of Necl-5/Tage4/PVR/CD155 and nectin, and of nectin and nectin during the formation of cell-cell adhesion. Cancer Sci. 96(9): 578-89.
        • Minami Y, et al. (2007) Involvement of up-regulated Necl-5/Tage4/PVR/CD155 in the loss of contact inhibition in transformed NIH3T3 cells. Biochem Biophys Res Commun. 352(4): 856-60.

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