CD146/MCAM Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

MCAM (Melanoma Cell Adhesion Molecule, also known as CD146; MUC18; HEMCAM; METCAM; MelCAM), located on 11q23.3, is a Protein Coding gene. The gene produces a 71607 Da protein composed of 646 amino acids. MUC18, a member of the immunoglobulin superfamily, is homologous to several cell adhesion molecules and is associated with tumor progression and the development of metastasis in human malignant melanoma. Diseases such as Noonan syndrome-like Disorder With Or Without Juvenile Myelomonocytic Leukemia and Melanoma are associated with MCAM.

CD146/MCAM Protein (4)

    CD146/MCAM Antibody (23)

      CD146/MCAM ELISA Kit & Match Antibody ELISA Pair Set (2)

      CD146/MCAM cDNA Clone (26)

      NM_006500.2
      NM_023061.2

      CD146/MCAM Lysate (3)

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        CD146/MCAM Background

        The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region, and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumors, and thus has been suggested to play an important role in tumor progression and the development of metastasis in certain human carcinomas.

        CD146/MCAM References

        • Mills L, et al. (2002) Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer Res. 62(17): 5106-14.
        • Taira E, et al. (2004) Characterization of Gicerin/MUC18/CD146 in the rat nervous system. J Cell Physiol. 198(3): 377-87.
        • Fritzsche FR, et al. (2008) CD146 protein in prostate cancer: revisited with two different antibodies. Pathology. 40(5): 457-64.
        • Bidlingmaier S, et al. (2009) Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res. 69(4): 1570-7.
        • Boneberg EM, et al. (2009) Soluble CD146 is generated by ectodomain shedding of membrane CD146 in a calcium-induced, matrix metalloprotease-dependent process. Microvasc Res. 78(3): 325-31.

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