CD133/PROM1 Proteins, Antibodies, cDNA Clones Research Reagents

PROM1 (Prominin 1) is a protein coding gene located on human chromosome 4p15.32. PROM1 is also known as RP41, AC133, CD133, MCDR2, STGD4, CORD12, PROML1 and MSTP061. The human PROM1 gene encodes a 97202 Da protein containing 865 amino acids. The PROM1 protein is broadly expressed in gall bladder, stomach and other tissues. Among its related pathways are Transcriptional misregulation in cancer and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. PROM1 is related to cadherin binding and actinin binding. PROM2 is an important paralog of PROM1 gene. PROM1 is associated with some diseases, including Macular Dystrophy, Retinal, 2 and Stargardt Disease 4.

CD133/PROM1 Protein (2)

    CD133/PROM1 Antibody (2)

      CD133/PROM1 cDNA Clone (28)

      BC012089
      NM_008935.2

      In cloning vector

      In lentiviral vector

      NM_001110137.1

      CD133/PROM1 Lysate (2)

        CD133/PROM1 Background

        CD133, also known as PROM1 and Prominin 1, is a pentaspan transmembrane glycoprotein that belongs to the prominin family. It localizes to membrane protrusions and is often expressed on adult stem cells. CD133 is known to play a role in maintaining stem cell properties by suppressing differentiation. CD133 binds cholesterol in cholesterol-containing plasma membrane microdomains. It is proposed to play a role in apical plasma membrane organization of epithelial cells. CD133 is also involved in regulation of MAPK and Akt signaling pathways. Mutations in PROM1 gene have been shown to result in retinitis pigmentosa and Stargardt disease. PROM1 gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Expression of this gene is also associated with several types of cancer.

        CD133/PROM1 References

        • Corbeil D. et al., 2001, Biochem Biophys Res Commun. 285 (4): 939-44.
        • Horn PA. et al., 1999, Blood. 93 (4): 1435-37.
        • Sanai N. et al., 2005, N Engl J Med. 353 (8): 811-22.

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