Catalogue | Product name | Purity | Endotoxin |
10400-H03H | Human CD4 / LEU3 Protein (His & Fc Tag) | > 92 % as determined by SDS-PAGE | < 1.0 EU/μg protein |
10073-H01H | Human CD14 Protein (Fc Tag) | > 97 % as determined by SDS-PAGE | < 1.0 EU/μg protein |
11880-H08H | Human CD19 / Leu-12 Protein (His Tag) | > 90 % as determined by SDS-PAGE | < 1.0 EU/μg protein |
80307-R08H | Rat CD68 / Macrosialin Protein (His Tag) | > 95 % as determined by SDS-PAGE | < 1.0 EU/μg protein |
10015-H01H | Human GM-CSF / CSF2 Protein (Fc Tag) | > 97 % as determined by SDS-PAGE | < 1.0 EU/μg protein |
10346-H03H | Human ICAM-1 / CD54 Protein (His & Fc Tag) | > 95 % as determined by SDS-PAGE | < 1.0 EU/μg protein |
10084-H02H | Human PD-L1 / B7-H1 / CD274 Protein (Fc Tag) | > 95 % as determined by SDS-PAGE | < 1.0 EU/μg protein |
10161-HCCH | Human CSF1R / MCSF Receptor / CD115 Protein | > 90 % as determined by SDS-PAGE | < 1.0 EU/μg protein |
11215-H08H | Human LAMP1 / CD107a Protein (His Tag) | > 95 % as determined by SDS-PAGE | < 1.0 EU/μg protein |
10148-H02H | Human CD31 / PECAM1 Protein (Fc Tag) | > 95 % as determined by SDS-PAGE | < 1.0 EU/μg protein |
50001-M08H | Mouse ANPEP / APN / CD13 Protein (His Tag) | > 97 % as determined by SDS-PAGE | < 1.0 EU/μg protein |
50078-M03H | Mouse ALK-3 / BMPR1A Protein (His & Fc Tag) | > 95 % as determined by SDS-PAGE | < 1.0 EU/μg protein |
The cluster of differentiation (or cluster of designation), often abbreviated as CD, is a protocol used for the identification and investigation of cell surface molecules present on white blood cells (cells of the immune system). The cluster of differentiation nomenclature was proposed for the classification of the many monoclonal antibodies (mAbs) generated by different laboratories around the world against epitopes on the surface molecules of leukocytes. Since then, the use of cluster of differentiation has expanded to many other cell types, and for humans CD is numbered up to 350 most recently (as of 2009).
The cluster of differentiation nomenclature was proposed and established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), which was held in Paris in 1982. Immunologists generated large numbers of monoclonal antibodies reactive with leukocyte cell-surface molecules, each with different associated nomenclatures. In the absence of comparative studies it was often impossible to tell if the same molecule was recognized by more than one antibody. The approach of the workshops was to code antibodies and to send them to multiple participating laboratories for blind analysis against multiple cell types. The data were collated and analyzed by the statistical procedure of "cluster analysis." This analytical method identified clusters of antibodies with very similar patterns of binding to leukocytes at various stages of differentiation: hence the "cluster of differentiation" (CD) nomenclature. The cluster of differentiation nomenclature allowed the scientific community to communicate results in a universal language.
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