CCL5/RANTES Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All CCL5/RANTES reagents are produced in house and quality controlled, including 3 CCL5/RANTES Antibody, 2 CCL5/RANTES ELISA, 52 CCL5/RANTES Gene, 1 CCL5/RANTES Lysate, 3 CCL5/RANTES Protein, 3 CCL5/RANTES qPCR. All CCL5/RANTES reagents are ready to use.

CCL5/RANTES Protein (3)

    CCL5/RANTES Antibody (3)

      CCL5/RANTES ELISA Kit & Match Antibody ELISA Pair Set (2)

      CCL5/RANTES cDNA Clone (52)

      NM_002985.2
      NM_013653.3
      NM_031116.3
      NM_001003010.1

      CCL5/RANTES Lysate (1)

        CCL5/RANTES Background

        Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokin ligand 5(CCL5) is chemotactic for T cells, basophils and eosinophils. Chemokin ligand 5(CCL5) has been considered a HIV-supressor secreted by CD8+ T cells and other immune cells. Chemokin ligand 5(CCL5) is a key to activating recruit leukocytes into inflammatory sites and in the presence of particular cytokines released by T cells, it can change the NK cells into CHAK cells.

        CCL5/RANTES References

        • Laing KJ, et al. (2004) Chemokines. Developmental and comparative immunology. 28(5): 443-60.
        • Cocchi F, et al. (1995) Identification of RANTES, MIP-1a, and MIP-1b as the major HIV-suppressive factor produced by CD8+ T cells. Science. 270 (5243): 1811-5.
        • Vangelista L, et al. (2010) Engineering of Lactobacillus jensenii to secrete RANTES and a CCR5 antagonist analogue as live HIV-1 blockers. Antimicrob. Agents Chemother. 54 (7): 2994-3001.
        • Maghazachi AA, et al. (1996) CC chemokines induce the generation of killer cells from CD56+ cells. Eur. J. Immunol. 26 (2): 315-9.

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