Cardiotrophin 1 Proteins Research Reagents

All Cardiotrophin 1 reagents are produced in house and quality controlled, including 2 Cardiotrophin 1 Lysate, 2 Cardiotrophin 1 Protein. All Cardiotrophin 1 reagents are ready to use.

Cardiotrophin 1 Protein (2)

    Cardiotrophin 1 Lysate (2)

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      Cardiotrophin 1 Background

      CTF1 is the first HOX11 protein partner identified that plays an important role in hematopoietic precursor cell immortalization. CTF1 was found to protect a gene from silencing when its DNA-binding sites were interposed between the gene and the telomeric extremity, while it did not affect a gene adjacent to the telomere. Protein fusions containing the CTF1 histone-binding domain displayed similar activities, while mutants impaired in their ability to interact with the histone did not. Cardiotrophin-1 (CTF1) has been reported to act as a trophic factor for a few neurons, such as sensory, cholinergic, dopaminergic, motor and cortical neurons. Studies have indicated that CTF1 delays degenerative disease progression in motor neuron disease.

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