carboxylesterase 2/CES2 Proteins, Antibodies, cDNA Clones Research Reagents

All carboxylesterase 2/CES2 reagents are produced in house and quality controlled, including 4 carboxylesterase 2/CES2 Antibody, 15 carboxylesterase 2/CES2 Gene, 2 carboxylesterase 2/CES2 Lysate, 2 carboxylesterase 2/CES2 Protein, 2 carboxylesterase 2/CES2 qPCR. All carboxylesterase 2/CES2 reagents are ready to use.

carboxylesterase 2/CES2 Protein (2)

    carboxylesterase 2/CES2 Antibody (4)

      carboxylesterase 2/CES2 cDNA Clone (15)

      carboxylesterase 2/CES2 Lysate (2)

        carboxylesterase 2/CES2 Background

        Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin. It also serves to hydrolyze long-chain fatty acid esters and thioesters. It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation. Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors.

        carboxylesterase 2/CES2 References

        • Imai T. et al. (2006) Human carboxylesterase isozymes: catalytic properties and rational drug design. Drug metab pharmacokinet. 21 (3): 173-85.
        • Guang Xu, et al. (2002) Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan. Clin Cancer Res. 8: 2605.
        • Zhang, et al. (2002) Comprehensive Evaluation of Carboxylesterase-2 Expression in Normal Human Tissues Using Tissue Array Analysis. Applied Immunohistochemistry & Molecular Morphology. 10 (4): 374-80.

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